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Gulf Coast Institute of Rejuvenation

Preferred Form of Replacement Therapy

The choice of the type of hormones used for symptom control and hormone replacement are the key to achieving optimal results.

Trans­der­mal estro­gens min­i­mize the devel­op­ment of clotting factors due to the fact that they do not have to first pass through the liver to be absorbed as occurs when med­ica­tions are taken orally.

The risk of devel­op­ing blood clots (deep vein throm­bo­sis or pulmonary throm­boem­bolism) with trans­der­mal estrogen therapy, is neg­li­gi­ble in com­par­i­son to that asso­ci­ated with oral estro­gens. Estrogen deficiency that occurs dur­ing menopause contributes to abdominal obesity, insulin resistance and could play a major role in the devel­op­ment of diabetes in women.

Estrogen is balanced with admin­is­tra­tion of natural prog­es­terone. A study conducted at three prestigious uni­ver­si­ties, including the Yale Uni­ver­sity School of Med­i­cine , concluded that natural prog­es­terone, enhances estrogen’s ben­e­fi­cial effects on heart muscle, prevents vasospasm and reduce arte­r­ial plaque for­ma­tion by 50% in post menopausal women. Prog­es­terone also induces the death of cancer cells , inhibits estrogen stim­u­lated spread of breast epithelial cells, which can reduce the risk of breast cancer, and has receptors in many vital areas of the body having ben­e­fi­cial effects on the heart, brain and bone. It is needed by all women, even those who have had a hys­terec­tomy, as prog­es­terone has many other purposes besides decreasing the risk of endome­trial cancer.

This is not true of Medrox­yprog­es­terone acetate (commonly known as Promethium and Provera). In fact, at Oregon Health Sciences Uni­ver­sity and USC School of Med­i­cine, synthetic medrox­yprog­es­terone was shown to constrict coro­nary arteries, causing vasospasm and heart attack, It is anth­apop­totic, which means that it does not cause cancer cells to die. It may sig­nif­i­cantly increase estrogen-stimulated breast cell pro­lif­er­a­tion, which can contribute to the devel­op­ment of breast cancer.

Hormone Replacement Therapy