Preferred Form of Replacement Therapy
The choice of the type of hormones used for symptom control and hormone replacement are the key to achieving optimal results.
Transdermal estrogens minimize the development of clotting factors due to the fact that they do not have to first pass through the liver to be absorbed as occurs when medications are taken orally.
The risk of developing blood clots (deep vein thrombosis or pulmonary thromboembolism) with transdermal estrogen therapy, is negligible in comparison to that associated with oral estrogens. Estrogen deficiency that occurs during menopause contributes to abdominal obesity, insulin resistance and could play a major role in the development of diabetes in women.
Estrogen is balanced with administration of natural progesterone. A study conducted at three prestigious universities, including the Yale University School of Medicine , concluded that natural progesterone, enhances estrogen’s beneficial effects on heart muscle, prevents vasospasm and reduce arterial plaque formation by 50% in post menopausal women. Progesterone also induces the death of cancer cells , inhibits estrogen stimulated spread of breast epithelial cells, which can reduce the risk of breast cancer, and has receptors in many vital areas of the body having beneficial effects on the heart, brain and bone. It is needed by all women, even those who have had a hysterectomy, as progesterone has many other purposes besides decreasing the risk of endometrial cancer.
This is not true of Medroxyprogesterone acetate (commonly known as Promethium and Provera). In fact, at Oregon Health Sciences University and USC School of Medicine, synthetic medroxyprogesterone was shown to constrict coronary arteries, causing vasospasm and heart attack, It is anthapoptotic, which means that it does not cause cancer cells to die. It may significantly increase estrogen-stimulated breast cell proliferation, which can contribute to the development of breast cancer.